BWAS Editorials


BWAS Editorials - 2023


Controversies on brain-wide association studies: commentaries from the field

By Mallar Chakravarty.

Since the earliest days of neuroimaging research, there has been a significant emphasis on data and code sharing at all stages of the experimental pipeline. There are clear advantages to this strategy and many in other branches of neuroscience have used the neuroimaging field as an exemplary model of how to engage in more transparent and reproducible science...



Behavioral phenotypes, stochastic processes, entropy, evolution, and individual variability: Toward a unified field theory for neurodevelopment and psychopathology

By Tonya White.

Twenty years ago during my postdoctoral research fellowship, I remember my mentor, Nancy Andreasen, telling me that when they first started neuroimaging studies in schizophrenia, their expectation was that they would “find the lesion,” identifying the underlying neurobiology of schizophrenia...



Lost in transformation: fMRI power is diminished by unknown variability in methods and people

By Peter A. Bandettini.

Over the past 40 years, MRI has had immense clinical impact on patient assessment and care, as lesions associated with trauma or disease are readily identifiable in individual patients....



On the statistics of brain/behavior associations

By Bertrand Thirion.

The paper by Marek et al. published in Nature, 2022, addresses a question central to brain–behavior association studies, or more precisely, brain-wide association studies: namely, how much data are necessary to carry out statistically meaningful inference and the importance of
replicating effects on independent cohorts...



Putting behaviour back into brain-behaviour correlation analyses

By Jeggan Tiego and Alex Fornito.

A fundamental challenge for human neuroscience is to relate imprecise measures of the brain with imprecise measures of behaviour...



Brain-behavior associations depend heavily on user-defined criteria

By Lucina Q. Uddin

Thanks to a recent massive study involving analysis of nearly 50,000 MRI datasets from the Adolescent Brain Cognitive Development (ABCD), Human Connectome
Project (HCP), and UK Biobank, we have learned that thousands of subjects are needed to arrive at the reproducible brain–behavioral phenotype associations using univariate analytic approaches...



Commentary on 'Reproducible brain-wide association studies require thousands of individuals'

By Sofie L. Valk, Meike D. Hettwer.

A primary assumption of cognitive neurosciences is that brain structure relates to its function and consequently to behavior. Indeed, inquiries assessing genetic relationships between genes and behavior indicate a genetic link, suggesting a shared biological basis...



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